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Tiger

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Understanding how genes turn on and off in different cell types remains a fundamental question in biology.

This intricate dance is orchestrated by cis-regulatory elements (CREs), which are regions of DNA that act as control switches for gene expression.

This newfound detail challenges the notion of a single, static gene controlling a specific trait as with the theory of evolution.

Instead, CREs act as a dynamic regulatory layer, potentially explaining how the same genes can give rise to diverse cell types within an organism. This challenges major tenets of neo-Darwinism – the linear relationship between genes and traits.

 

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Blind Cavefish: Evolutionary Icon, or an Example of Preprogrammed Adaptation? - by Emily Reeves


However, there is another model that could explain the transformations of the cavefish. This model is called continuous environmental tracking (CET) and it is design-based. The model presupposes that organisms actively track conditions within specific environments and self-adjust based on predesigned adaptation trajectories. Similar to human engineered agile systems, organisms can make internal changes within a range in response to external changes. This model posits: ...
 

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No random mutations, no imaginary selection
Bacteria Quickly Fix a Faulty Motor by Rearranging DNA - In a couple of days.


The ability of bacteria to quickly reconfigure their genomes to restore flagellar function exemplifies the profound intelligence inherent in biological design. These processes are far too intricate and rapid to be the product of random mutations and slow evolutionary pressures. Instead, they reveal a purposeful and highly organized approach to genetic information management, affirming the concept of intelligent design.

This discovery not only challenges the traditional evolutionary paradigm but also provides a deeper understanding of the remarkable capabilities embedded within the DNA's passive, yet meticulously organized information library.

The rapid genetic changes observed in bacteria serve as a testament to the inherent intelligence and foresight embedded in the blueprint of life.



 

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Queen bees and worker bees are genetically identical organisms. They become two different life forms because the queen eats 'royal jelly'. The same principle is seen in humans.


It's an intricate balanced system where genes are coded themselves by other sources of information

 

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DNA “grammar” discovered!

DNA is considered the language of life and has bases that we often refer to as letters. In genes, the letters make up 3 letter words (codons) that code for amino acids. When the DNA of a gene is “read” (or transcribed and translated) the amino acids make a protein which has a specific structure and function. Of course, all these processes are highly regulated! You have the same DNA in brain cells and liver cells, but you want brain cells to produce brain proteins and liver cells to produce liver proteins.

It appears an important part of that regulation is “spatial grammar.” The activity of transcription factors (proteins that turn genes “on or off”) depends on the location of their binding site relative to the gene. We used to think transcription factors (TFs) acted as only activators OR repressors, but it turns out their activity is based on SPACING in the DNA sequence. The article linked in this post stated, “this research shows the function of transcription factors is far more complex.”

Exactly! Far more complex than anyone would imagine something that supposedly came about by random chance over eons of time. There are layers and layers of information that we continue to discover.


 

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It's much more complex than anyone could imagine

Nature Reviews Genetics: This Review describes the roles of individual histone variants in multiple processes, including gene regulation, DNA replication and DNA repair, and the cellular consequences of their dysfunction.

 

jpc

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Queen bees and worker bees are genetically identical organisms. They become two different life forms because the queen eats 'royal jelly'. The same principle is seen in humans.


It's an intricate balanced system where genes are coded themselves by other sources of information

So then!
A millennial consumption of soy latte over decades?
 

Tiger

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So then!
A millennial consumption of soy latte over decades?
Ha, yeah. If you ‘are what you eat’, then someone should be taking a careful look at diets of young people in the last few decades.
 
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jpc

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Ha, yeah. If you ‘are what you eat’, then someone should be taking a careful look at diets of young people in the last few decades.
That's switching on and off a few gene sequences all right.
 

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Queen bees and worker bees are genetically identical organisms. They become two different life forms because the queen eats 'royal jelly'. The same principle is seen in humans.


It's an intricate balanced system where genes are coded themselves by other sources of information

The fact that queen bees are queen bees because of what they consume is news to.. absolutely fucking nobody (I can post a video of Dawkins (who's a biologist) saying this)

Can you please expand on how this expounds your intelligent design thesis? 🤔
 

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The fact that queen bees are queen bees because of what they consume is news to.. absolutely fucking nobody (I can post a video of Dawkins (who's a biologist) saying this)

Can you please expand on how this expounds your intelligent design thesis? 🤔

Jambo. Why is it that nuance seems to escape you like a well-hidden Easter egg? Not everything needs to come with a step-by-step manual.

The point isn’t just that food can change how bees grow, but that this shows how carefully their bodies are made to work.

Of course the development of queen bees through their consumption of royal jelly is well-established and widely understood, I’m not claiming otherwise.

However, the point I’m making in relation to Intelligent Design (ID) is not about the fact of the queen bee's development, but rather what this kind of precise, programmed response suggests about the underlying biological systems. The question isn't whether environmental factors influence development, but whether the intricacy of these mechanisms, like epigenetic switches and highly coordinated gene expression, could plausibly arise from random evolutionary processes alone (they can't), or whether they point to a pre-installed, purposeful design. Such highly specific and finely tuned biological systems — where a single environmental input can dramatically alter an organism's development — suggests strongly a guiding intelligence behind life's architecture. The fact that this process works so seamlessly and reliably is what expands the discussion beyond known biology into questions about the origins of such complexity.

The concept of epigenetics, wherein gene expression is dynamically regulated by external factors, aligns with ID claims of "directed adaptability." Instead of emerging through random evolutionary processes, such complex and highly coordinated regulatory networks are viewed as exhibiting characteristics of irreducible complexity, with multiple interacting components working seamlessly to produce a coherent biological response. This adaptability, framed within the larger context of fine-tuning, supports the argument that life is the product of intentional design, as the intricate balance between organism and environment is far too precise and specific to have arisen purely by chance. Thus, the capacity for diet and other environmental factors to reprogram genetic expression strengthens the ID argument for a purposive, intelligent origin of life systems.
 
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